![]() ![]() ![]() Lightspeed Venture Partners led the Series B round and was joined by investors including Polychain Capital, Ribbit Capital, Redpoint Ventures, Pantera Capital, Alameda Research, and Mark Cuban. Offchain Labs, a New York City-based company tackling scaling for Ethereum, raised $120 million in funding. “There are a bunch of companies that aren’t as relevant anymore and are being replaced by, say, Stripe.” When asked last year why he thought more solo capitalists were appearing, Gil hypothesized the coming of a new wave of companies is playing a role in the surge: “I also think this is a trend because there’s been a sudden shift in which networks are really important,” he told Term Sheet, pointing to the rise of the PayPal mafia as an example of this dynamic. The trend of the solo investor in short, doesn’t appear to be going away anytime soon. And now, in a sign that limited partners are betting that he will continue to be able to win deals against traditional VC firms, the investor is now raising a $620 million fund-the largest amount raised by a solo fund manager, per the Information. Read the story here.ĮLAD GIL: The storied venture capitalist is the prime example of the new class of solo capitalist-single investors that are able to move fast and lead sizable deals in startups. And it is these risky derivatives that allow users to put leverage on bets that are parent company FTX’s main line of business, one that helped turn it into a now $18 billion company. This matters because it allows FTX.US-which has up to now, offered a limited set of products compared to its parent company-to offer derivatives, a class of assets that includes the likes of futures. To Ghodsi, the questions signalled that Counterpoint was thinking about the long-term of the business-a trait founders commonly say they seek in investors.įTX.US’S DEAL: FTX.US, the stateside arm of the crypto exchange FTX, will acquire LedgerX, a derivatives exchange with a license from the Commodity Futures Trading Commission. ![]() Lynch asked scenario-planning questions too: “How do you keep a culture of innovation and make sure your employees are taking enough risk? Who do you promote-the who pulled an all-nighter, or the one who came up with a high-risk project?” Lynch asked about “how do you see things over the next decade, what kind of leaders are in your company, what is acceptable behavior in the company,” says Ghodsi. It helped that the two teams had known each other for a while previously. Early news of the deal, which was officially announced Tuesday, had previously been covered by Newcomer and Bloomberg.Īccording to the co-founder, who held his last round of fundraising only in February, Counterpoint’s Head, Dennis Lynch, asked multiple hours of questions about the company’s culture rather than the typical line of inquiry, for example, on the company’s current competition. So it was interesting to hear Databricks CEO Ali Ghodsi describe one of the reasons why Morgan Stanley’s Counterpoint Global is the lead investor for its $1.6 billion round of funding, valuing the business at about $38 billion: The line of questioning. There’s plenty of talk at this time in fundraising about venture capitalists winning deals by offering ever larger checks, especially in the later stages of fundraising. ![]()
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![]() 14 Technically, a protein scaffold ( Fig. ![]() Based on the discoveries of small molecule proteins with binding function and the gradual development of biotechnology, it is feasible to confer targeting ability to small size proteins by mutating the variable region. Hence, urgent demands for addressing these limitations have motivated scientists to explore novel antibody alternatives. 11 While truncated antibodies such as antigen-binding fragments (Fab/scFvs) and alpaca nanobodies have been developed to remedy the shortcomings of full-size antibodies, some defects remained, such as lower avidity after modification and the requirement of humanization processing for reducing immunogenicity. In addition, in some situations, the antibody constant fragment (Fc) might incur immune-related cytotoxicity, resulting in damage to normal tissues and organs. 10 Moreover, it may be difficult to introduce free residues and chemical linkers for further drug conjugation. 9 Posttranslational modifications are indispensable in facilitating the production of antibodies with complete functionality however, these require the use of a high-cost and time-consuming eukaryotic expression system, which limits the large-scale production and access to most patients. For instance, the large molecular weight leads to poor tissue penetration for solid tumors, and hinders the binding of inside antigenic epitopes and the internalization of antibody-conjugated drugs. 7,8 However, several defects deter the further application of antibodies. Antibodies can recognize biomarkers on cell surfaces, thereby activating immune responses or suppressing protumoral biological activities. 5,6 Generally, antibodies are large size proteins, which comprise two pairs of heavy and light chains that form a stable Y-shape structure via disulfide bond linking. Monoclonal antibodies against tumor markers are the most widely investigated targeting elements for precise cancer diagnosis and treatment. 1 To deal with these issues, precision medicine using multi-omics information analyses has been proposed to identify the crucial tumor markers for classifying patients and tailoring precisely targeted treatments. Traditional cancer treatments were designed as one-size-fits-all approaches however, not all patients benefited from the same method owing to inter- and intra-tumor heterogeneity between individuals. Introduction Cancer is a severe disease that threatens human health. In this review, we focus on the protein scaffold applications in cancer therapy and diagnosis in the last 5 years, and discuss the pros and cons, and strategies of optimization and design. To date, more than 20 types of protein scaffolds have been developed, with the most frequently used being affibody, adnectin, ANTICALIN®, DARPins, and knottin. Given the properties of small size, high affinity, and excellent specificity and stability, protein scaffolds have been applied in basic research, and preclinical and clinical fields over the past two decades. By combining robust gene engineering and phage display techniques, libraries with sufficient diversity could be established for target binding scaffold selection. Protein scaffolds are small monomeric proteins with stable tertiary structures and mutable residues, which emerged in the 1990s. These issues have led scientists to explore and develop novel antibody alternatives. Although antibodies are well developed and widely used in cancer therapy and diagnostic fields, some defects remain, such as poor tissue penetration, long in vivo metabolic retention, potential cytotoxicity, patent limitation, and high production cost. ![]() ![]() ![]() Prior to his appointment as an Assistant Attorney General, James served as research staff on several grants through the University of Washington Psychology Department. Additionally, he represented the Department of Social and Health Services in child abuse and neglect cases and projects with the agency’s Government Operations Division. James primary clients are the Department of Intercollegiate Athletics, KUOW, the Trademark Office, UW Marketing and Communication (UMAC), the Treasury Office, UWINCO, the Tax Office, and the Office of Research.īefore joining the UW Division, his work at the Attorney General’s Office included prosecuting involuntary civil commitment trials against sexually violent predators throughout the State. James has served with the University of Washington Division of the Attorney General’s Office since December 2014. Practice Areas: Athletics, Intellectual Property (trademark and copyright), Media Law, Sponsorships, Tax law, Commercial law, Finance and Investment law, Research Law (sponsored programs).Undergraduate Degree: University of Washington (B.A., Psychology, 2000).Law Degree: Seattle University School of Law (Seattle University) (J.D., 2005, magna cum laude).District Court for the Western District of Washington) Admitted to Practice: 2005 (Washington), 2011 (U.S.Prior to joining the University of Washington Division, Daniel worked in the Government Compliance and Enforcement Division prosecuting professional misconduct cases for the Department of Health, primarily litigating matters before Nursing Care Quality Assurance Commission and other healthcare boards and commissions. Undergraduate Degree: University of Washington (B.A., English, 2004)ĭaniel has served with the Attorney General’s Office since 2012.Law Degree: Seattle University School of Law (Seattle University) (J.D., 2010, cum laude).Admitted to Practice: 2010 (Washington).Prior to his time with the UW Division, David was with the Social and Health Services Division, where he represented the Department of Social and Health Services in child abuse and neglect cases, and then with the Antitrust Division for five years handling all aspects of government civil enforcement of state and federal antitrust laws in Washington State. During his tenure with the UW Division, he has also advised Pharmacy, School of Medicine, and Compliance, among other University clients. Before assuming the role of Division Chief, David was a member of the Healthcare Team and his primary client was UW Medicine. In July 2019 David was named Division Chief for the UW Division. Practice Areas: Higher Education, Healthcare Lawĭavid has been an Assistant Attorney General since 2008, and with the University of Washington since 2015.Undergraduate Degree: University of Washington.Law Degree: Washington College of Law, American University.Admitted to Practice: 2004 (Washington). ![]() At, you can run a person's phone number, email address or name, and the site will give their workplace details. Provided you have the person's details, Radaris will allow you to find where someone works since it has numerous tools to help you conduct your searches. Hit the “Search“ button to find the most populated streets in that area, including properties and residents. To find who lives on your street, visit and enter that street's address, city, state, or zip code. On the reports that appear, look for the one with birth dates similar to the person you are looking into. Simply visit the site and enter a person's first name and carry out a search. Like most people's finder websites, Radaris provides users with the birth dates of the people they are looking for. How to find someone with first name and birthday? You can find arrest records for Jessica Fink in our background checks if they exist. Does Jessica Fink have a criminal record? We have marriage records for 103 people named Jessica Fink. Jessica Fink's email address is We have 5 additional emails on file for Jessica Is Jessica Fink married? Jessica Fink's address is 3014 Salmon St, Portland, OR 97214. (269) 649-0990, (269) 649-2856, (616) 649-9950ġ6329 Rocketts Mill Rd, Doswell, VA 23047ġ22 Saint Edward Pl, Palm Bch Gdns, FL 33418ġ1504 177Th Street Ct, Illinois City, IL 61259ħ338 Willow Creek Dr, Ypsilanti, MI 48197ġ0110 Tanner Rapids Ct, Las Vegas, NV 89148ĩ11 Bedford Ave APT 4, Brooklyn, NY 11205Ģ255 W Orange Grove Rd APT 910, Tucson, AZ 85741įAQ: Learn more about our top result for Jessica Fink What is Jessica Fink's address?
![]() ![]() It is usually a sweet, soft cake that may be flavored with cinnamon, nuts, fruit, or other ingredients. Looking for Fun Things to do with Kids in LA? You’ll love this book! This handy-dandy, portable paperback book is packed full of ideas for FUN all over SoCal! Keep it in the car, your purse, your diaper bag – and be ready for fun anytime, anywhere! LAUSD Coffee Cake FAQsĪ: Coffee cake is a type of cake that is traditionally served with coffee or tea. The ingredients are simple, although not all of us may have nutmeg or buttermilk on hand. The original, likely mimeographed*, version of the recipe is attached below. ![]() Enjoy! /I3DbjPScqH- Austin Beutner August 16, 2018 Here’s the 1954 recipe of the famous coffee cake. Someday it would be awesome to see how they’ve adapted it to make enough to serve 350,000 at a time, but for now, we have this. One day, as I was scrolling on Twitter, I saw that Austin Buetner, the Superintendent of LAUSD, had tweeted out the original 1954 recipe. (Middle School Administrators and Food Service workers, please take note.) The LAUSD 1954 “Old Fashioned” Coffee Cake Recipe I don’t want to overstate how delicious this Coffee Cake is, but let me just say this: My then-10-year-old son decided what Middle School he wanted to attend because they served him this Coffee Cake when he visited as a 5th grader. Even though the recipe dates back to 1954, the LAUSD Coffee Cake is still delicious today! ![]() ![]() When brewing coffee, you might use a French Press, pour-over, drip coffee machine, Aeropress, espresso machine, or one of the other popular methods to extract flavor from coffee grounds using hot, or in the case of cold brew, room-temperature water. What's important for now, is the Americano is a coffee drink, a way of serving coffee, and not a coffee brewing method. A long black is also made with espresso and water, but the way it is made is different from an Americano. Well, it’s not quite that simple, but that’s the core of it. The definition: What is an Americano coffee?Īn Americano is an espresso diluted with water. Also, we’ll sort out the confusion between an Americano, and a long black. But what is an Americano coffee? We’re going to guide you through everything you need to know about an Americano what it is, where it came from, why it’s different from regular coffee, how to make one, and show you some variations on the original drink. You might be surprised to learn that the Americano has been around for a long time and is a popular drink among true coffee lovers. And if you turn to coffee or espresso for the concentration and energy benefits, check out our roundup of supplements that can help you stay sharp and focused.Among the drinks on the menu of most good coffee shops, you’ll find the Americano (or an Caffé Americano if you're fancy). "Since good-quality sleep is important for overall health, including immunity and metabolism, you might want to keep your coffee drinking to daytime hours," says Li.Īt the end of the day, Li recommends titrating the amount you drink to your own tolerance levels since everyone responds to coffee and caffeine differently. Consume no more than 400 milligrams of caffeine per day, and try to stop drinking caffeine around noon-or even earlier if you're sensitive. "Added sugars stress your metabolism, while artificial sweeteners can damage your healthy gut bacteria," he says.Īnother pro tip: Don't overdo it, and give yourself a cutoff point. First: Steer clear of added sugar-that includes refined sugar and artificial sweeteners, according to Li. Now that we've established that both coffee and espresso can fit into a healthy lifestyle, there are some necessary caveats we have to share. This means that lightly roasted and medium roasted coffees will have a higher concentration of these healthy plant compounds than dark roasted coffees-a category that espresso typically falls into. The more a coffee bean is roasted, the lower its chlorogenic acid content falls 10. The amount of beneficial chlorogenic acid in your brew is affected by its roasting process. It's no wonder that metabolic health expert Alexis Cowan, Ph.D., recently named coffee as one of her grocery essentials for healthy metabolism on the mindbodygreen podcast. ![]() (FYI: One in three adults currently has metabolic syndrome.) In the study, researchers found that participants who drank more than three cups of coffee per day had lower BMI, waist circumference, blood pressure, and triglycerides, as well as higher HDL cholesterol than study volunteers who drank less than 1 cup per day. One study published in the European Journal of Nutrition 9 looked at coffee's effect on metabolic syndrome, a group of conditions that can increase the risk of diabetes, heart disease, and other chronic health conditions. Plus, the high antioxidant count in coffee makes it a beverage of choice among longevity experts. "īecause of these beneficial compounds, coffee consumption has been associated with a lower risk of heart disease 7 and improved cognitive functioning 8. "These include protection of the circulatory system, activation of metabolism, and reduction of inflammation 6. "All coffees contain natural bioactive substances, one of which is chlorogenic acid, which has important health benefits," says Li. Both coffee and espresso can be good sources of bioactive plant compounds that contribute to your health when you drink them responsibly. ![]() ![]() SketchBook Pro Desktop and SketchBook Motion are the only versions of SketchBook with animation tools. 0:00 / 14:13 Autodesk Sketchbook app Tutorial for tablet (with subtitles ) Poh’s Studio 7.27K subscribers Subscribe 316K views 3 years ago Hey guys this is a basic tutorial on how to draw using. However, before we get into the differences, one thing to keep in mind is that any image created in SketchBook can be imported into either one of these animation packages, as a flattened image. ![]() You can treat the strong stabilizer as a kind of a Sketchbook Pro pen tool Second, the Predictive Stroke function predicts what shape you're trying to draw, and attempts to make it more accurate. SketchBook Pro Desktop has FlipBook animation tools, such as keyframes and a timeline, to bring your images to life. 1 - a line without the stabilizer, 2 - a line with a subtle stabilizer, 3 - a line with a strong stabilizer. With SketchBook Motion, you can turn an image into a moving story, add meaning to a presentation, build simple animated prototypes, design dynamic logos and ecards, create fun and engaging classroom projects, and enhance instructional content. The all-new SketchBook - Flipbook - Part 1 You can check out some of our FlipBook tutorials by following the YouTube links below:Īnimation in SketchBook Pro Desktopĭo you love FlipBook animation and want to create fun images that come to life? If so, try FlipBook! It is available to anyone running a desktop version of SketchBook. The all-new SketchBook - FlipBook - Part 2 Different uses for animation Have you ever used SketchBook to sketch a concept, annotated it, adding other sketches to try to get an idea across? Next time, create a FlipBook. Get started with Autodesk drawing and sketching software with these tutorials and lessons. Imagine sending someone a sketch that comes to life to better illustrate your concept. With FlipBook, you can create cell animation, a prototype, or proof of concept. Thomas used FlipBook to create this short Chasing Christmas on Vimeo. ![]() Normally, tracing isn't a proper way to create art, but today we're studying painting, not drawing. Introducing the Sketchbook Premium Bundle on Android and iOS. Use the Pencil or the Inking Pen to draw the lines. Open your reference in Sketchbook Pro, lower its Opacity a little, and create a new layer. SketchBook Motion was named iPad App of the Year for 2016. How to Start a Painting Step 1 First, we need some kind of line art. ![]() ![]() Added new delegate method to UAInAppMessagingDelegate that can control when a message is able to be displayed.Apps using Scenes & Surveys should update. Minor release that adds support for randomizing response order in a Survey, adds a new delegate method to InAppMessageManager that controls when a message can be displayed, and fixes several issues with Scenes & Surveys reporting. Youtube URLs have been removed from the default urlAllowListScopeOpen. Media URLs for In-App experiences are no longer checked on the allow list. The SDK Allow list has been updated to allow opening all URLs by default if neither urlAllowList or urlAllowListScopeOpen have been set in the config.Default In-App Automation display interval has been changed from 30 seconds to 0 seconds.Actions rewritten to be sendable and are now only available from Swift.Added a new PushNotificationStatus publisher that provides the current status of push notifications.Fixed several sendable warnings throughout codebase.Config -> AirshipConfig, Channel -> AirshipChannel, etc. Renamed several classes throughout the SDK to prevent API collisions for simple classes, e.g.A majority of the completionHandler APIs have been replaced with async functions.ExtendedActions module has been removed and actions have been merged into other modules.Accengage, Chat, and Location modules have been removed. ![]() The provided Preference Center UI has been rewritten in SwiftUI.The provided Message Center UI has been rewritten in Swift & SwiftUI.Message Center module has been rewritten in Swift. ![]()
![]() If you’re careful, there’s no reason you can’t start sooner. Some argue that any pruning except to remove unhealthy growth is inappropriate until your Japanese Maple is 10-15 years old. Here’s a quick guide to pruning your Japanese Maple at the various stages of its life cycle:ĭon’t Prune Young Japanese Maples More Than You Have To How Old Should A Japanese Maple Get Before You Prune It? Japan’s native Acer trees have a natural elegance, but savvy pruning can often enhance and emphasize their inherent beauty. It’s always best to choose a variety with a mature size that fits the space, but the right pruning techniques can help you keep your tree on the small side.įinally, you can prune your Japanese Maple to help define its shape as it grows. You can combine this practice with some structural pruning to steer its growth away from nearby structures and walkways. And densely packed branches with little airflow are more susceptible to disease.Ĭlipping back a Japanese Maple may also help you limit its size. Lack of sunlight can stifle the foliage on the lower or shorter branches, limiting your maple’s energy intake. If the tree’s canopy is too dense (particularly in the “weeping” varieties), not much light or breeze can get through. And you should take off any branches showing signs of diseases like wilt, cankers, and leaf or twig blight.Ĭorrect pruning can also improve the overall health of your Japanese Maple and encourage vigorous growth. It’s best to remove this dead tissue before it rots and spreads decay to the healthy parts of the tree. ![]() Extreme heat or cold can damage these trees, and it’s not uncommon to see a bit of dieback during both winter and summer. The most common type of trimming is a simple cleanup cut to remove dead or dying growth. While it’s good to be conservative with your cuts, there are actually quite a few scenarios where pruning your tree is the right move. We think that’s a bit of an exaggeration. To hear some gardeners tell it, there’s basically no reason ever to trim your Japanese Maple. See below for our detailed instructions on the right way to trim a Japanese Maple. These trees grow slowly, so if you’re not certain you should make a particular cut, it’s often okay to think it over for a year or two! The only exception is removing dead or diseased wood, which should happen as soon as possible. One important thing to remember as we proceed: less is often more when it comes to pruning Japanese Maples. ![]() ![]() It’s best to prune a Japanese Maple in the summer (for size) or the winter (for shape). Careful trimming can also help you control its size. As the tree matures, you should occasionally thin out the canopy to increase light and airflow. Read on to learn the best times, techniques, and tools for Japanese Maple pruning.Ī young Japanese Maple needs very little pruning, though a few cuts in the right places can help steer it toward a pleasing shape. However, there’s a good case to be made that you should prune a Japanese Maple occasionally if you want the healthiest, best-looking tree possible. As a result, many gardeners wonder if there’s any need to trim them at all. Does your Japanese Maple need pruning? These trees seem to effortlessly develop an elegant structure as they grow. ![]() ![]() ![]() Notifcations can also pop up if you have the Amazon app on your smartphone or tablet. ![]() ![]() You can either change the phone number that gets text notifications or unsubscribe altogether. Go to Accounts & Lists > Your Account > Communication and content > Communication preferences > Shipment updates via text. If you get SMS notifcations, you can do the same thing. From there, you can change what email address will be notified when something is ordered on Amazon. But you can control where that email goes.įrom the Amazon home page, go to Accounts & Lists > Your Account > Communication and content > Communication preferences > General settings. No matter what, you’ll always get emails when you place an order, once it’s shipped, and once it’s delivered. Control notifications. You can't disable all Amazon notifications. Go to Accounts & Lists > Your Account > Archived Orders if you need to call them up again.)ģ. (Don’t worry you can always see your archived orders. Underneath everything you’ve ordered, you’ll see a link that says “Archive Order.” This will remove it from your list of orders. Archive orders. If you don’t want someone seeing the gift by snooping on your past orders, this is a quick fix. Fortunately, there are further tricks you can use.Ģ. And it won't solve your Amazon gift problem if you also share your account with college-age kids or other adults. But with the holidays nearly here, you might feel too rushed to set up Households. ![]() ![]() ![]() ![]() Noooow back to the nachos, which are finally done the right way at this point! Serve 'em as is, or offer up some salsas on the side- I like to eat mine with salsa verde but I always put out some mild red salsa as well for the ones who don't care much for the green stuff, like the weirdos I live with. I save the extras for topping tacos, pulled pork, and burgers, too. Combine that all in a container with 1 cup of water and let it sit for at least an hour, and bam, you've got quick pickles for all of your nacho needs. All you need is a red onion, a couple of hot red finger peppers or jalapenos, apple cider vinegar, sugar, and salt. Oh yeah, the quick pickles- I almost forgot mention those. I like to top my nachos with quick pickled onions and spicy red pepper slices, avocado, sprouts, green onion, cilantro, and a drizzle of sour cream. But if you're anything like me and you want your nachos to be crazy-over-the-top tasty, then you're not quite done yet. Now, if you're not a perfectionist, feel free to eat the nachos just like that, and I promise that you won't be disappointed. I repeat until all of the layers are assembled, and then pop it into the oven briefly to melt the shredded cheese, warm everything back up, and get it all toasty on top. I place a third of the nachos at the bottom of a cast iron skillet, and top generously with pork, fresh pineapple, crumbled queso fresco, shredded pepper jack, and the cheddar cheese sauce. I like to put my nachos together in layers, so that there are no bare bites. Then, I melt the starched cheese in a pot with evaporated milk, which creates a smooth, velvety, creamy cheese sauce that is perfect for nachos. ![]() I toss cheddar cheese with cornstarch, which prevents the melted cheese from breaking or getting grainy. Once I have the pork covered, I move on to that queso I keep on mentioning. Don't worry, it's still crazy delicious, despite being not-so-traditional. However, I wanted to make this nacho version a bit simpler (and leave myself more time for makin' some queso), so I subbed in ancho chile powder and upped the amount of chipotle chiles instead. When I make the meat for tacos, as you can check out in this Tacos Al Pastor recipe, I rehydrate dried chiles for the marinade, which is well worth the effort if you can find them. But it is insanely good none-the-less, and anyone can make it. Is it the exact same as bonafide al pastor meat? No, I won't even pretend for a second that it is. Instead, I cheat and cut my pork into small chunks before marinating and searing it in my cast iron skillet. Unfortunately, I don't own a trompo, and odds are you don't either- but if you do, invite me over, PLEASE. Al pastor is typically shaved from the vertical rotisserie (which is called a trompo) and spooned into tortillas in heaps of tangy, spicy, smoky porky goodness. The Lebanese technique of spit-firing meat on a vertical rotisserie (as would be used in shawarma) was readily adopted in Mexico, but Mexicans used a marinade of dried chiles, pineapple, and spices on pork rather than typical Middle Eastern seasonings with chicken, beef, or lamb. Tacos al pastor are Central Mexican tacos which originated as a result of the influence of Lebanese immigrants. For those of you who haven't tried them yet, let me tell you what all the hype is about: Personally, tacos al pastor are my all-time favorite traditional taco. You've probably heard of tacos al pastor before, and if you're lucky (or dedicated enough), you've probably eaten them. ![]() Yeah, doing it right means Nachos Al Pastor, baby. The Right Way™ requires 3 types of cheese (for crumbling, shredding, and queso-ing), plenty of produce (from pineapple to sprouts to avocado), and most importantly, piles of spicy pork. But I do have to say that sometimes you have to splurge a little and do nachos the right way, and yes, there is a right way. I make no claim to the title of Nacho Elitist I'll eat 'em even if they're microwaved, smothered in fake cheese, and soggy-bottomed- they are nachos, after all. ![]() |
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